A close-up look at 20,000 individual cells

Researchers at INAC have successfully used a technique initially developed for molecular analysis to observe 10,000 to 20,000 cells at once. The advance hinges on using breakthrough optics to give SPRi (surface plasmon resonance imaging) micrometer resolutions, even for large observation fields. The researchers improved both the plasmon propagation length and image sensor, boosted the image cadence, and corrected optical artefacts.
The next step will be to use their new version of SPRi to observe lymphocyte secretion—which in real-life conditions involves just one out of every 1,000 cells—in real time. By analyzing the phenomenon, researchers hope to identify areas for future exploration in immunology.

Contact: loic.leroy@ujf-grenoble.fr

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