BHI-PRO project reaches milestone in automated protein quantitation

Leti and bioMérieux recently teamed up to conduct quantitative protein measurements using MRM mass spectrometry with automated data processing and sensitivity levels of around 10-8. The research was part of the BHI-PRO* project funded by the French National Research Agency (ANR). The partners’ Bayesian inversion software performs just as well as—and, in some cases, better than— bioMérieux’s existing system. Plus, it does not require an operator’s supervision.
The detection of tiny variations in the proteins expressed in a patient’s blood could ultimately be used to make early diagnoses of diseases like cancer, atheroma, and septicemia. However, the dilution is so low that even seemingly-insignificant fluctuations can render the measurements inaccurate—a constraint that the BHI-PRO software accounts for. The software should soon be transferred to bioMérieux for implementation.

*with CEA-List, IMS, LBS, and CLIPP

Contact: pierre.grangeat@cea.fr; laurent.gerfault@cea.fr

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